The Hv1 Voltage-Gated Proton Channel: Are Two Pores Better than One?

The Voltage-Gated Proton Channel Hv1 Has Two Pores, Each Controlled by One Voltage Sensor

In voltage-gated channels, ions flow through a single pore located at the interface between membrane-spanning pore domains from each of four subunits, and the gates of the pore are controlled by four peripheral voltage-sensing domains. In a striking exception, the newly discovered voltage-gated Hv1 proton channels lack a homologous pore domain, leaving the location of the pore unknown. Also unk...

Selectivity Mechanism of the Voltage-gated Proton Channel, HV1

Voltage-gated proton channels, HV1, trigger bioluminescence in dinoflagellates, enable calcification in coccolithophores, and play multifarious roles in human health. Because the proton concentration is minuscule, exquisite selectivity for protons over other ions is critical to HV1 function. The selectivity of the open HV1 channel requires an aspartate near an arginine in the selectivity filter...

Voltage-Sensing Domain of Voltage-Gated Proton Channel Hv1 Shares Mechanism of Block with Pore Domains

Voltage-gated sodium, potassium, and calcium channels are made of a pore domain (PD) controlled by four voltage-sensing domains (VSDs). The PD contains the ion permeation pathway and the activation gate located on the intracellular side of the membrane. A large number of small molecules are known to inhibit the PD by acting as open channel blockers. The voltage-gated proton channel Hv1 is made ...

Two Are Better than One?

This paper uses Markov-switching specifications to create a hybrid model with time-varying loading on each of chartist and fundamentalist approaches. The empirical data include the U.S. dollar exchange rates of four Asian tiger countries’ currencies including NTD, SGD, HKD and KOW from 1980 to 2000. Our empirical findings are consistent with the following notions. First, the forecasting perform...

The Voltage-gated Proton Channel Hv1 Is Required for Insulin Secretion in Pancreatic β Cells